Neurodegeneration in Autoimmune Optic Neuritis Is Associated with Altered APP Cleavage in Neurons and Up-Regulation of p53.

Multiple Sclerosis (MS) is a chronic autoimmune inflammatory disease of the central nervous system (CNS).Histopathological and radiological analysis revealed that neurodegeneration occurs early in the disease course.However, the pathological mechanisms involved in neurodegeneration are poorly understood.Myelin oligodendrocyte glycoprotein (MOG)-ind

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Complex Organisms Must Deal with Complex Threats: How Does Amphibian Conservation Deal with Biphasic Life Cycles?

The unprecedented rate of global amphibian decline is attributed to The Anthropocene, with human actions triggering the Sixth Mass Extinction Event.Amphibians have suffered some of the most extreme declines, and their lack of response to conservation actions may reflect challenges faced by taxa that exhibit biphasic life histories.There is an urgen

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Evaluation of the physical structure of Basic Health Units

Objective: to evaluate the infrastructure of basic health units, as the adaptation to the standards recommended by theMinistry of Health.Methods: descriptive study with a quantitative approach, carried in 18 basic health units.For datacollection, we used a checklist built based on Ministerial Decree 2,226/09.Data analysis was performed using the St

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Role of Culture Shock as a Mediator of Relationship between Achiever and Challenger Personality to Sojourner Adjustment

Students who continue their education abroad will be vulnerable to stress and other adaptation problems.Success in overcoming new pressures and situations, one of which is determined by the personality characteristics of each person.This research aims to determine the role of culture shock as a mediator of the relationship between the personality o

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State and Problems of Religious Life in Ukraine

The only indicators of religious life that are currently fixed by state authorities are existing religious organizations.The official statistics PTC Start Relay of the religious network, submitted by the State Committee on Nationalities and Religions in early 2008, recorded the presence of 33841 religious organizations in Ukraine in more than one h

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